Electrocardiographic studies during hypotensive anaesthesia using sodium nitroprusside

Accentuated hypotensive effect of sodium nitroprusside in man after captopril.

1. The effects of graded intravenous infusions of sodium nitroprusside on resting blood pressure and heart rate and on the reflex changes in these variables evoked by a standardized Valsalva manoeuvre were studied in six normal subjects. The effects of nitroprusskle on the above variables were also studied after pretreatment with captopril, to allow assessment of the role of angiotensin 11. 2. ...

The use of sodium nitroprusside as a hypotensive agent in plastic surgery.

THE use of sodium nitroprusside for hypotension during plastic surgical operations has been investigated at the Queen Victoria Hospital, East Grinstead, in a series of twelve cases. An attempt has been made to compare its effectiveness with that of the pharmacological blockers, and to determine whether controls such as posture and respiration are similarly responsible for its hypotensive action...

Sodium Nitroprusside Injection

Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...

Electrocardiographic studies during cardiac surgery.

Deliberately Lowering Blood Pressure with Sodium Nitroprusside

The goal of hyptensive anesthesia is the safe reduction of intraoperative blood loss, thus reducing transfusion risks.  Previous hypotensive technics had a narrow margin of safety in that cardiac output was usually reduced in proportion to the degree of induced hypotension. This is in contrast to the results of our study, in which Sodium Nitroprusside was used as the sole hypotensive agent. Ni...